miR-200b was overexpressed in patients with bone metastasis (FC = 12.4, P = 0.03, AUC = 0.70), bilateral tumor (FC = 5.22, P = 0.03, AUC = 0.64), and PSA level > 10.0 ng/μL (FC = 5.08, P = 0.03, AUC = 0.63) (Fig 4A and 4B). This evidence concerns the gene KLK3 and neoplasm.