Recent results have shown that aspirin reduces SOD-1 aggregation in amyotrophic lateral sclerosis (ALS) and decreases amyloid aggregates in Alzheimer’s diseases (AD) by donating its acetyl to decrease phosphorylation, which suggests that acetylation might contribute to the neuroprotective and lifespan extension effects of aspirin [13]. The gene discussed is SOD1; the disease is Alzheimer disease.