For the mechanism of action in anti-cancer and chemoprevention activities, aspirin and salicylic acid can directly bind to CDK2 and down-regulate cyclin A2/CDK2 proteins [37] and inhibit CBP and p300 lysine acetyltransferase activity in vitro through direct competition with acetyl-Coenzyme A at the catalytic site [38]. This evidence concerns the gene EP300 and cancer.