Differences in directionality (negative or positive association) of the PCs with CIMT by pregnancy history may reflect either processes of cellular activation that might reflect differences of increased body mass index, hypertension, and insulin sensitivity or the depletion of activated cells from the circulation due to adherence to other blood-borne cells or the vascular endothelium, or participation in micro-thrombosis in the capillaries. Here, INS is linked to hypertensive disorder.