EDN1 and ischemia: The decrease in ATP levels during this period indicates that the increase in inflammatory cells, congestion, impairment of tissue integrity and oedema provoked the development of rigor-type contracture.35 In the case of ischaemia-associated coronary endothelial dysfunction, the vasodilator response is reduced because the increase in endothelin-1 level, a potent vasoconstrictor, which is formed in the process, causes vasoconstriction and leads to a decrease in blood flow.37