Interestingly, higher levels of POPX2 were observed in multi-drug resistant cells such as HL-60/MX2 and TC7 than their parental cells HL-60 (human promyelocytic leukemia cells) and Caco-2 (human colorectal adenocarcinoma cells), respectively. The gene discussed is PPM1F; the disease is acute promyelocytic leukemia.