Compared with the other inhibitors that only impede kinase activity, DHI may not only block IKK kinase activity but also abrogate the kinase-independent activity of IKK.32, 33 Moreover, it has been shown that mutation of IKK can confer cancer cell resistance to an IKK inhibitor.47 Therefore, DHI may provide an alternative approach to overcome this drug resistance. Here, CHUK is linked to cancer.