Unexpectedly, IKKβ knockdown decreases p65 in nucleus, but did not change the nuclear p-p65 and overexpression of p65 partially abrogates the proliferation inhibitory effect of DHI on NHL cell lines, these data suggest that the inhibitory effect of knockdown of IKKα/β might be p65 phosphorylation independent. This evidence concerns the gene IKBKB and non-Hodgkin lymphoma.