HSPA5 and cancer: SERCA has been identified as a therapeutic target for various cancers.31, 32 SERCA inhibitors such as TG have been shown to induce autophagic cell death due to the disruption of calcium homeostasis.8, 33 As expected, RL71 induced ER stress as supported by the accumulation of unfolded proteins and an elevation of Grp78, ATF4 and CHOP.