The native phospholipase A2 induced an increase in the plasma creatine kinase (CK) values of 368 ± 63 (n = 6), whereas the administration of 8CR at concentrations of 60 μg (2.4 mg/kg) and 180 μg (7.2 mg/kg) effectively decreased the myonecrosis activity induced by the native sPLA2 (CK values of 182 ± 34 and 52 ± 16 U/L, respectively; n = 5, * p ≤ 0.05; Figure 3B). Here, PLA2G4A is linked to gas gangrene.