We found that the two hypertensive strains exhibited abnormal enlargement and mild injury in their livers before HFC feeding, as shown by the lower serum TC levels and higher ALT levels in both the hypertensive strains as well as by the higher serum AST levels only in the SHR rats, which suggests that some intrinsic factors associated with hypertension may have affected the development of hepatic inflammation. This evidence concerns the gene GPT and Hypertension.