Therefore, nuclear factor erythroid 2-related factor 2 (Nrf2) signaling as well as its target gene heme oxygenase-1 (HO-1), which is important for antioxidant defense [20,21,22], may also be involved in the progression of hypertension-associated NASH. This evidence concerns the gene HMOX1 and metabolic dysfunction-associated steatohepatitis.