In the present study, we investigated the roles of these pathways, NF-κB, MAPK, and Nrf2, as well as their interaction in the pathogenesis of hypertension-associated NASH using three strains, i.e., normotensive WKY, hypertensive SHR, and SHRSP5/Dmcr. The gene discussed is NFKB1; the disease is hypertensive disorder.