As shown in Figure 5, of the genes participating in metal ion binding (MIB1, KAT6B, ITGA8, HBAC, KCNC1, and F13A), most were downregulated during the later stages of GCRV infection, whereas genes involved in protein ubiquitination (HERC1 and HERC4) were upregulated during the later stages of infection. The gene discussed is ITGA8; the disease is infection.