In line with our previous findings [13] and those of others in models of alcohol- and endotoxin-induced intestinal barrier dysfunction [31,49] as well as animal models of necrotizing enterocolitis (for an overview see [50]), in the present study, protection against the loss of tight junction proteins was associated with protection against the induction of MMP-13 and iNOS mRNA expression in intestinal tissue. Here, NOS2 is linked to necrotizing enterocolitis.