Moreover, the expression of MyD88 mRNA and iNOS protein, as well as 4-HNE protein adducts in the liver—which have been previously shown to be highly dependent on the endotoxin-dependent activation of the TLR-4 signaling cascade in settings of diet-induced NAFLD [15,18,19]—were also significantly higher in the FFC-fed mice. Here, TLR4 is linked to metabolic dysfunction-associated steatotic liver disease.