In vitro, IL-6 has been shown to increase hepatic DBP production,[16] and IL-6 is raised in obesity and may also play a role in relation to the higher concentrations of DBP in the obese women in our study.[17] Also, it has been reported that the DBP gene is moderately expressed in rat adipose tissue.[18]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.