IGHE and Down syndrome: Although GT is most commonly observed in psoriasis, its coexistence with diabetes mellitus, hormonal disorders, reactive bronchitis, asthma, eczema, hay fever, atopy, elevated serum IgE, other chronic inflammatory conditions, bacterial infections, anemia, dietary deficiencies, such as vitamin B complex and iron deficiency, Reiter syndrome and Down syndrome has been reported as well [18, 182].