Dividing patients into tertiles based on ELISA titers, renal failure tended to occur more frequently in patients belonging to the group in the highest tertile (PLA2R-Ab titer > 610 U/ml) and these patients had a significantly lower incidence of spontaneous remission compared to the lowest (PLA2R-Ab titer 41–175 U/ml) tertile (4 versus 38%, resp). This evidence concerns the gene PLA2R1 and Renal insufficiency.