As shown in Table 1, transmembrane protein 108 (TMEM108), C3orf47 and coenzyme Q8A (CABC1) were the top three genes positively correlated with tumor grade, whereas ladinin 1 (LAD1), TIAF1 and FGF11 were the top three genes negatively correlated with the tumor grade of ESCC patients. Here, H1-10-AS1 is linked to esophageal squamous cell carcinoma.