The expression level of TIAF1, LAMB3 and PPARG was statistically different between ESCC tissues and matched mucosa tissues; however, the expression levels of GOLGA7B, GOLGA1, ARNT2 and CDKN1A were not statistically different between ESCC and matched mucosa tissues. The gene discussed is CDKN1A; the disease is esophageal squamous cell carcinoma.