The ROC analyses showed that the AUC of CDKN1A, GOLGA7B and TIAF1 was greater than 0.85, indicating that CDKN1A and GOLGA7B might be potential biomarkers for discriminating ESCC patients with G1 (well‐differentiated) from those with G3 (poorly‐differentiated). Here, CDKN1A is linked to esophageal squamous cell carcinoma.