As shown in Table 1, transmembrane protein 108 (TMEM108), C3orf47 and coenzyme Q8A (CABC1) were the top three genes positively correlated with tumor grade, whereas ladinin 1 (LAD1), TIAF1 and FGF11 were the top three genes negatively correlated with the tumor grade of ESCC patients. The gene discussed is COQ8A; the disease is esophageal squamous cell carcinoma.