NF-κB is a transcription factor that mediates antiapoptotic signals inseveral cancer cell types, and the inhibition of the NF-κB signalingpathway induces apoptosis in cancer cells.22,23 NF-κB can blockPAR-4-mediated apoptosis by the downregulation of the tracking of PAR-4 receptor GRP78from the ER to the cell surface.24 We foundthat BFA enhanced the phosphorylation of IκBα protein inTC-1 and HeLa cells. The gene discussed is NFKBIA; the disease is cancer.