CASP3 and neoplasm: However, a role of BFA in theactivation of CHOP was very little in TC-1 tumor cells and Atg5+/+ andAtg5−/− MEF cells (Supplementary Figure 2).The results indicated that ER stressors initiate apoptosis of TC-1 tumor cells throughthe activation of the caspase-12/caspase-3 pathway.