We elucidated a novel mechanism of miRNA self-regulatory activity whereby the oncogenic expression of the RNA-binding protein hnRNPA1 is downregulated by miR-25-3p and/or miR-15a-5p, which causes hnRNPA1 (a facilitator of miR-18a-3p) in turn to downregulate the expression of tumor-suppressor miR-18a-3p, thus leading to an increase in the expression of K-RAS required for increasing survival in ovarian cancer chemotherapy-resistant cells (Figure 6). Here, HNRNPA1 is linked to ovarian cancer.