Cells in which hnRNPA1 was silenced, however, showed no change in proliferation with hnRNPA1 siRNA treatment (Supplementary Figure S3b); moreover, these cells expressed greater aggressiveness as determined by a multiplex assay showing increases in pro-invasive factors such as matrix metalloproteinases (MMPs) MMP-1 and MMP-9 and in pro-angiogenic factors such as fibroblast growth factor (FGF)-2, vascular endothelial growth factor (VEGF)-D and VEGF-C, which have important roles in tumor-mediated migration, invasion and angiogenesis (Supplementary Figure S3c and d). This evidence concerns the gene MMP1 and neoplasm.