SERPINE1 and Sepsis: Previously, Koyama et al. [13] measured various coagulation/fibrinolysis markers in sepsis patients and reported that thrombin-antithrombin complex (TAT), PAI-1, and protein C discriminated well between patients with and without overt DIC (area under the receiver operating characteristic curve [AUROC], 0.77, 0.87 and 0.85, respectively) and, using the three together, significantly improved the AUROC up to 0.95.