There are several DSRCT features which suggest its mesothelial origin: it resembles morphologically the small cell variant of epithelial mesotheliomas, shows dot-like immunostaining for desmin (similar to that described in fetal and adult mesothelial cells), and immunostaining for NSE (as described in large part of malignant mesotheliomas). This evidence concerns the gene ENO2 and malignant mesothelioma.