The improved lens opacity and diabetic retinopathy in diabetic rats were attenuated by the combination extract of mango seed and the aerial parts of Vietnamese coriander (MPO) at all dosages used in this study whereas the decreased MDA level was observed only in diabetic rats which received MPO at doses of 2 and 10 mg/kg·BW. The gene discussed is MPO; the disease is diabetic retinopathy.