EGFR and cancer: However, additional studies must be conducted to establish the precise key role of lncRNAs in targeted therapies, such as EGFR-TKIs, associated to functional epigenetic mechanisms among others, PRC2 (EZH2 and SUZ12 proteins) and/or TRX Activator Complex (SWI/SNF/CoREST proteins), directly involved to the PTMs of the histone code in cancer epigenomics.