TP53 and neoplasm: Liu and colleagues reported a MEG3 (Maternally Expressed 3 Gene) decreased expression in tumor tissues from patients insensitive to cisplatinum and in a cisplatinum-resistant A549 lung adenocarcinoma cells (A549/DDP), while the ectopic expression of MEG3 in A549/DDP may contribute to increased cisplatinum chemosensitivity through the regulation of p53 and Bcl-xl expression-induced mitochondria apoptosis pathway.