POU5F1 and lung cancer: Aside from that, it has previously been reported how SOX2-OT overexpression correlates with malignant stem-cell like phenotype, positively associated with the SOX2 and POU5F1 (also known as OCT4) protein level expression, poor overall survival, and poor therapy efficacy in lung cancer patients [88], likely in correlation with a transient recruitment balance among TRX versus PRC2.