A likely lncRNAs profile will include, among others, HOTAIR, MEG3, NEAT1, UCA1, and/or AK126698 in cancer-drugs cisplatinum-based therapies, and the recently proposed GAS5, UCA1, BC087858 and SOX2-OT involved in the gene-target therapies as EGFR-TKIs based oncological treatments (Fig. 3). The gene discussed is MEG3; the disease is cancer.