SOX2 and cancer: On the other hand, Liu et al., reported the abnormal overexpression of HOTAIR in lung tumors of NSCLC patients resistant to cisplatinum-based treatment, as well as lung cancer resistant A549/DDP cells, confirming that HOTAIR is involved in cisplatinum resistance and involved in the expression induction of cancer stem-like cells biomarkers, such as β-catenin, Nanog, Oct3/4, SOX2, Klf4 (Krüppel-like factor 4), and c-Myc.