PRDM9 and lung adenocarcinoma: Finally, it has been experimentally demonstrated that inactivation of SWI/SNF complex members SMARCA4 (BRG1) or ARID1A has adverse effects on malignancy in early-stage lung adenocarcinomas, while loss of the histone methyltransferase Setd2 and subsequent loss of H3K36me3 led to the accelerated malignant progression at both early- and late-stage lung adenocarcinoma tumors [34].