In this regard, overexpressed lncRNAs H19 and BC200 have previously been validated; in contrast, HOTAIR and MALAT1 have been found to be downregulated in gefitinib-resistant lung cancer cells, suggesting that such differential expression patterns for several lncRNAs are frequently involved in EGFR-TKIs treatment resistance mechanisms in human NSCLCs [80] (See Table 2). The gene discussed is EGFR; the disease is lung cancer.