KCNQ1OT1 and cancer: Additionally, miRNAs such as let-7c have shown to be negatively correlated with lncRNAs such as CCAT1, suggesting a functional sponge archetype between miRNAs and lncRNAs, as shown in Fig. 2, regulating, as a whole, sensitivity or resistance to cancer-drug docetaxel in NSCLC tumors [75], while lung AD patients and AD A549/PA cells resistant to paclitaxel have shown overexpression of the lncRNA KCNQ1OT1 (KCNQ1 Opposite Strand/Antisense Transcript 1) in correlation with tumor growth, poor histological differentiation, positive lymphatic metastasis, and advanced TNM clinical stage.