Finally, a probable connection with EGFR-TKIs therapy efficacy may be associated as it has recently been demonstrated between lncRNA SOX2-OT overexpression in lung SCC versus lung AD histological types, associated with a poor survival rate in lung cancer patients (studying a cohort of 83 lung cancer patients) and involved in lung cancer cell proliferation and SOX2 coding gene overexpression. The gene discussed is SOX2; the disease is lung carcinoma.