The downregulation of one of these lncRNAs, namely AK126698, in NSCLC cisplatinum-resistant cells suppressed the induction of apoptosis induced by cisplatinum in A549 cells, possibly through decreased naked cuticle homolog 2 (NKD2) expression and increased β-catenin expression, accumulation and nuclear translocation resulting in an altered WNT cellular signaling pathway and significantly depressed apoptosis induced by cisplatinum in lung cancer A549 cells. The gene discussed is NKD2; the disease is lung carcinoma.