ALOX5 and hereditary elliptocytosis: Figure 5 shows the serum levels of the various inflammatory markers. MIA induced the production of IL-1β, IL-6, and TNF-α in serum. Consistent with the above data, the serum levels of IL-1β and TNF-α were significantly lowered by LJF-HE at a dose of 100 mg/kg. It was also noted that the serum levels of IL-1β and TNF-α were comparable in the LJF-HE-treated (100 mg/kg) and IM-treated (1 mg/kg) rats (Figures 5(a) and 5(c)). Furthermore, MIA-induced increases in the serum levels of LTB4 and 5-LOX were significantly inhibited by LJF-HE (Figures 5(d) and 5(e)).