According to Shichita et al., the efficient internalization of DAMPs, such as high-mobility-group box 1 (HMGB1), peroxiredoxins (PRXs), S100A8, and S100A9, is mediated by macrophage scavenger receptor 1 (MSR1) and macrophage receptor with collagenous structure (MARCO) in a murine model of ischemic stroke. This evidence concerns the gene MSR1 and ischemic stroke.