The first three were derived from in vitro models, including the post-translational activation of a Myc-ER chimera in mouse 3T9MYC-ER fibroblasts (Sabò et al. 2014), as well as the conditional expression of recombinant tet-MYC protein in human osteosarcoma (U2OStet-MYC) (Walz et al. 2014) and B-cell lines (P493-6) (Lin et al. 2012). The gene discussed is MYC; the disease is osteosarcoma.