Collectively, our findings suggest that the early biological response is extensively altered by IL-1 deficiency, and although IL-1α and IL-1β may not be crucial components of MWCNT-induced fibrosis, this observation hints at an important role for these genes in sensing the damage elicited by MWCNTs. This evidence concerns the gene IL1B and hyperinsulinemic hypoglycemia, familial, 4.