AGT and obesity due to melanocortin 4 receptor deficiency: Although obesity-related traits such as BMI and WC did not differ according to AGT, AGTR1, or ACE genotypes between HBP and NBP subjects, overweight combined with obesity were much more common in boys with the ACE ID + DD genotype compared to ACE II carriers with high SBP (p = 0.04) (data not shown).