LBX1 and B-cell chronic lymphocytic leukemia: Focusing on DM gene hubs which are associated with long TtD (Additional file 2: Table S14) and therefore may play a role particularly in the early stages of CLL pathogenesis, the presence is noted of multiple developmentally important homeobox genes and transcription factors, implying developmental deregulation as an important part of early perturbations during CLL pathogenesis, as also indicated by the GO terms identified from the corresponding functional analysis (Additional file 2: Table S11).