The top genes in the DM and DE profiles include multiple genes related to the transport of ions and other small molecules (SEC14L1, SLC43A2, ATP9B, ABC6 and MCOLN2), as well as genes with GTPase-related activity (RASA3 and TBCD), however the role of these genes in CLL pathogenesis is not known. The gene discussed is RASA3; the disease is B-cell chronic lymphocytic leukemia.