FOXP3 and hepatocellular carcinoma: To substantiate tumor suppressive activity of FOXP3, we knocked down and over-expressed FOXP3 in HCC cell lines Hep3B (Hep3B-shFOXP3 and Hep3B-FOXP3, respectively) and 97H (97H–shFOXP3 and 97H–FOXP3, respectively).