EGFR and non-small cell lung carcinoma: Recently, a randomized, international, open-label, phase 3 trial (AURA3), comparing Osimertinib with platinum therapy plus pemetrexed in patients with T790M-positive advanced NSCLC (including those with CNS metastases) in whom disease had progressed during first-line EGFR-TKI therapy, have shown a significant improvement in progression-free survival (PFS), objective response rates (ORR) [39].