Meanwhile, inhibition of immune checkpoint factors such as PD-1 and PD-L1 has yielded good clinical responses and improved overall survival in certain NSCLC patients, however, only 15–20% of NSCLC patients respond to such therapy and affordability is another serious issue, since a single-course (7-month) treatment will cost more than $100,000 [4, 5]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.