Guichard et al. [3] performed a high-resolution copy-number and functional analysis in 125 HCC samples, finding four novel driver genes(ARID1A, RPS6KA3,NFE2L2 and IRF2) not previously reported in HCC and the inactivation of IRF2 could lead to a damaged TP53 function. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.