TEK and hepatocellular carcinoma: Regorafenib, a new oral multikinase inhibitor that targets VEGFR1-3, PDGFR β, FGFR and tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (TIE2, also known as angiopoietin-1 receptor), showed a broad spectrum of antitumor activity (inhibiting tumor angiogenesis and cell proliferation) as second-line treatment for intermediate or advanced HCC (stage B or C) [85].