Among several E-selectin ligands [248–252], Death Receptor-3 (DR3) is a signaling receptor for E-selectin in metastatic colon carcinoma cells [253] that can induce a rapid activation of p38 that increases the motile potential of cancer cells and favors their transendothelial migration [246, 253]. The gene discussed is TNFRSF25; the disease is cancer.