TEK and neoplasm: These inflammatory cells, particularly the macrophages present within the tumor microenvironment promote ECM degradation and tumor cell motility, which activates endothelial cells and thus enable angiogenesis, Furthermore, a subset of monocytes expressing Tie2, an angiopoietin receptor, are recruited to some cancer sites where they initiate neo-vascularization via different signals including hypoxia [204–206].