Various parameters have been reported in previous studies for predicting the prognosis of OSCC, including clinicopathologic features (clinical stage, tumor differentiation, tumor size, and treatment types, etc.)[5–7], serum biomarkers (C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), etc.)[8, 9], human papillomavirus (HPV) infection [10] and patients’ lifestyle factors (smoking, alcohol drinking, oral hygiene, etc.)[11, 12]. Here, CRP is linked to neoplasm.