Results showed that resveratrol negatively regulated expression of Ac-FoxO1 and p-FoxO3a (p<0.01) (Figure 4C, 4D), revealing that resveratrol decreased phosphorylation of FoxO3a (by inactivating K-Ras/PI3K/AKT signal) and acetylation of FoxO1 with SIRT1 up-regulation to induce apoptosis in spontaneous neoplasms. This evidence concerns the gene FOXO1 and neoplasm.