In the annual fish, resveratrol down-regulated acetylation of K-Ras, phosphorylation of FoxO3a, acetylation of FoxO1 and phosphorylation of DLC1 by SIRT1 or SIRT1-mediated inactivation of K-Ras/PI3K/AKT signal, and inhibited cell proliferation and promoted cell apoptosis in spontaneous neoplasms. The gene discussed is FOXO1; the disease is neoplasm.