CISH and colonic neoplasm: We found that in colon cancer HT29 cells, inward SOCs activated maximally (–4.6 ± 0.7 pA/pF and 6.8 ± 1.4 pA/pF, n = 31 cells) in strong intracellular Ca2+ buffer with no slow inactivation (Figure 4A, 4D).