Of the up-regulated genes common to zebrafish tumors and human medulloblastomas, most of them are involved in cell cycle progression (ccnb1, cdk2, mycl, wee1, etc.)and/or DNA replication, initiation, and elongation (mcm2, mcm4, mcm7, etc., Figure 8A, Supplementary Table 3) and primarily annotated to medulloblastoma associated genes (DisGeNET, http://www.disgenet.org/web/DisGeNET/menu/home) [22]. The gene discussed is WEE1; the disease is medulloblastoma.