Immunostaining with epithelioid MPNST marker, S100β, showed strong expression in spindle-shaped tumor cells (Figure 2D, 2D’) while the mesenchymal marker, Vimentin, also showed extensive staining in tumor tissues of cdkn2a/b TALEN mRNA injected tp53e7/e7 mutant zebrafish (Figure 2E, 2E’). The gene discussed is VIM; the disease is neoplasm.