During analysis of cdkn2a/b mutants, we encountered an unexpected observation that adult tp53 mutant zebrafish via one-cell stage injection of cdkn2a/b-TALEN mRNA could develop tumor mass, mainly occurring adjacent to the eyes as early as 6 to 7 months of age (Figure 1C, Table 1). The gene discussed is CDKN2A; the disease is neoplasm.