Despite a previous study indicating that RASSF6 inhibits cell growth and migration in HT29 and Lovo cell lines [19], further underlying mechanisms is needed to determine how RASSF6 suppress proliferation and metastasis in CRC, and to determine whether the expression level of RASSF6 correlates with the prognosis of CRC patients. Here, RASSF6 is linked to colorectal carcinoma.