JUN and neoplasm: Additionally, the canonical target genes mediate the effects of Wnt signalling in normal and diseased cells, and RASSF6 overexpression led to a distinct reduction in the Wnt signalling target genes c-Myc, c-Jun, and TCF1, along with a decrease in cell growth and motility; however, the specific target genes that mediate the ability of RASSF6 to act as a tumour suppressor in CRC have not been elucidated.