RASSF6 and neoplasm: First, we investigated the underlying molecular mechanisms through which RASSF6 inhibited tumorigenesis in CRC, which enriched and deepened the study reported by Chen et al. Secondly, except for negative correlation between RASSF6 expression and advanced TNM stage, we also found that low RASSF6 expression was significantly associated with tumour size (p = 0.042), lymph node status (p < 0.001), and the presence of distant metastasis (p < 0.001, Table 1), which provided more powerful evidence that RASSF6 suppresses CRC proliferation and metastasis.