Investigation of PCa cohorts within TCGA revealed miR-331-3p was significantly down regulated in tumor tissue vs normal adjacent benign prostate tissue (Table 3) and also that RALA and PLCγ1 were positively correlated ( ̃540 samples (cor=0.162, p<0.001); Supplementary Figure 1B). The gene discussed is PLCG1; the disease is posterior cortical atrophy.