In univariate and multivariate Cox regression, the results demonstrated The CFL1 (HR = 3.381, 95% CI = 2.020–5.659, p < 0.001) and PGK1 (HR = 2.509, 95% CI = 1.563–4.030, p < 0.001) over-expression were associated with the glioma progression (Figure 5D–5F). Here, CFL1 is linked to central nervous system cancer.