It is to note that present study results are based on data derived form a small animal number, and one dose: 8 mg/kg/day, and this dose was chosen based on our previous study showing this dose promoted atherosclerosis formation in ApoE−/− mice fed normal diet [14], and studied just on one time point (24 weeks), these factors indicate the preliminary nature of reported study results. Here, APOE is linked to atherosclerosis.