Moreover, besides the potential mechanistic observed in this study, other inflammatory factors, such as macrophage 1 and 2, galectin 3 and 1 may be involved in the METH-induced atherosclerotic plaque formation in this model, future studies with examinations on above inflammatory factors might help to reveal the potential mechanisms of atherosclerosis formation post METH use in this model. Here, LGALS3 is linked to atherosclerosis.