Only complexes 1, 2 and 5 were found to display collateral sensitivity in p53-deficient colon cancer with resistant factor ranged from 0.52 to 0.59 (Table 4 and Supplementary Figure 10), whereas 1 and 2 demonstrated the most potent and lowest IC50 values in p53-deficient colon cancer. Here, TP53 is linked to colonic neoplasm.