For instance, platinum ion containing cisplatin (cis-[PtII(NH3)2Cl2]) is the well-known FDA approved anti-cancer agent, which has been found to induce apoptosis via Akt, PKC or MAPKs signaling pathways [20] and has long been used to treat colon, ovarian and lung cancers. The gene discussed is PRRT2; the disease is lung carcinoma.