In most tumors such as breast, ovarian, prostate, lung carcinoma, and cutaneous melanoma, the tumor microenvironment includes a number of factors, such as CSF-1, VEGF, CCL2, IL-4, IL-13, TGF-β, and IL-10, which can recruit monocytes and lead to differentiation for M2-like phenotype [10–12]. The gene discussed is VEGFA; the disease is neoplasm.