Selecting large intestine cancer and colon cancer cell lines as filtering criteria, 34 of the proteins (ACTB, ACTR3, AHCY, ALDH2, ANXA2, ANXA3, ANXA5, ATP5B, CTSD, GANAB, GCC2, GSS, GSTO1, GSTP1, HNRNPC, HSP90AB1, HSPA5, HSPA8, HSPB1, HSPD1, KRT19, EB1, MVP, NDUFS3, NME1, OPA1, PPA1, PRDX3, SPECC1L, SUCLA2, TUBA1B, TUBB4B, UBA1, YWHAZ) were identified as markers associated with colon cancer. The gene discussed is HSP90AB1; the disease is colonic neoplasm.