Selecting large intestine cancer and colon cancer cell lines as filtering criteria, 34 of the proteins (ACTB, ACTR3, AHCY, ALDH2, ANXA2, ANXA3, ANXA5, ATP5B, CTSD, GANAB, GCC2, GSS, GSTO1, GSTP1, HNRNPC, HSP90AB1, HSPA5, HSPA8, HSPB1, HSPD1, KRT19, EB1, MVP, NDUFS3, NME1, OPA1, PPA1, PRDX3, SPECC1L, SUCLA2, TUBA1B, TUBB4B, UBA1, YWHAZ) were identified as markers associated with colon cancer. This evidence concerns the gene ALDH2 and malignant colon neoplasm.