Selecting large intestine cancer and colon cancer cell lines as filtering criteria, 34 of the proteins (ACTB, ACTR3, AHCY, ALDH2, ANXA2, ANXA3, ANXA5, ATP5B, CTSD, GANAB, GCC2, GSS, GSTO1, GSTP1, HNRNPC, HSP90AB1, HSPA5, HSPA8, HSPB1, HSPD1, KRT19, EB1, MVP, NDUFS3, NME1, OPA1, PPA1, PRDX3, SPECC1L, SUCLA2, TUBA1B, TUBB4B, UBA1, YWHAZ) were identified as markers associated with colon cancer. This evidence concerns the gene HSPA5 and colonic neoplasm.