FOXO3 and neuroblastoma: This findings not only confirmed a previous study which showed that FOXO3a transcriptionally regulates the expression of PDGFRα in neuroblastoma cells [42], but also revealed that FOXO3a activity is negatively regulated by mTORC1 (Figure 4), which was consistent with a previous study indicating that inactivation of mTORC1 induces nuclear accumulation of FOXO3a [43].