This finding, in addition to explaining the notably suppressed expressions of pressure/volume overload, LV hypertrophy and remodeling biomarkers (i.e., BNP, β-BMC) in LVIs/LVIs-CKD + ECSW animals, raises the need for a clinical prospective study to evaluate the effectiveness of ECSW treatment in patients with CKD/ESRD who have calcified/diffuse CAD unsuitable for coronary interventions (i.e., PCI or CABG) and refractory to optimal medication for angina pectoris. The gene discussed is NPPB; the disease is chronic kidney disease.