To further elucidate the role of the PD-1/PD-L1 axis in CM, and its potential interrelationship with the tumor microenvironment, we studied PD-1/PD-L1 expression and the presence of tumor-infiltrating lymphocytes (TILs) in a cohort of primary CM, and compared expression and (co)localization of these factors to clinical and histological characteristics. Here, CD274 is linked to neoplasm.