The following clinical parameters were not associated with moderate-to-severe weight gain in female breast cancer patients: tumor size (p=0.9), lymph node status (p=0.6), tumor type (p=0.3), estrogen receptor (p=0.1), progesterone receptor (p=0.8), HER2 status (p=0.5), Ki67 (p=0.3), chemotherapy (p=0.5), hormone therapy (p=0.6), indicator of cancer severity (p=0.7), menopausal status (p=0.3) and cause of menopause (p=0.5). This evidence concerns the gene ESR1 and neoplasm.