Other authors created an autophagic score, compromising of the staining patterns of ATG5, Beclin1 and LC3B, and found that a low autophagic score correlated with a worse prognosis in CRC or demonstrated that a combination of Beclin1, LC3B and Bcl-xL (classically thought of as apoptosis marker) also showed better prognostic discrimination than analysis done on single staining [14, 16]. The gene discussed is BECN1; the disease is colorectal carcinoma.