To explore whether LKB1 mediates the inhibitory effects of KIF7-CC in PCa, KIF7-CC-overexpressing PC3, C4-2B and 22Rv1 cells were lentivirally transduced with either LKB1 short hairpin RNAs (shRNAs: shH and shM) or a non-target control (shNTC) sequence to generate stably repressed cells or control cells. The gene discussed is KIF7; the disease is posterior cortical atrophy.