Furthermore, we identified that KIF7-CC increased LKB1 expression and its phosphorylation at Ser428 in PCa cells, which induced LKB1 to bind and phosphorylate PTEN at Ser380/Thr382/383 and then inhibited AKT phosphorylation at Ser473 (Figure 5). Here, STK11 is linked to posterior cortical atrophy.