KIF7 and posterior cortical atrophy: To determine whether KIF7 downregulation was associated with epigenetic regulation in PCa, LNCaP, DU145 and PC3 cells were treated with a DNA methyltransferase inhibitor (5-AZA-2’-deoxycytidine, 5-AZA-dC) or a histone deacetylation inhibitor (Trichostatin A, TSA) to investigate the effect of DNA methylation or histone deacetylation on KIF7 expression.