Additionally, it is identified that different single nucleotide polymorphisms (SNPs) of CXCL12 participates in various disease such as neck and head squamous cell carcinoma [12], myelodysplastic syndromes [13], multiple sclerosis [14], etc. Here, we choose six SNPs (rs1065297, rs1801157, rs266089, rs197452, rs2839693 and rs10793538) of CXCL12 to explore which SNPs are associated with the risk of CAD. This evidence concerns the gene CXCL12 and multiple sclerosis.